學界展開針對貓咪的基因改造計劃以 - 貓

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標題: [新聞] 學界展開針對貓咪的基因改造計劃以
時間: Sat Apr 2 14:19:28 2022

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1.媒體來源:

外媒 BGR

2.記者署名:

By Joshua Hawkins

3.完整新聞標題:

Scientists might actually create hypoallergenic cats

學界展開針對貓咪的基因改造計劃以降低過敏性

4.完整新聞內文:

Scientists might actually create hypoallergenic cats

學界展開針對貓咪的基因改造計劃以降低過敏性

Home Science News

By Joshua Hawkins
April 1st, 2022 at 4:17 PM
cat

People with cat allergies may be able to have a cat sometime in the future
thanks to gene-editing technology. Of course, the creation of truly
hypoallergenic cats is far off. But, scientists believe they could use
CRISPR, a gene-editing tool, to remove the gene responsible for creating the
protein that causes cat allergies.

借助基因編輯技術，對貓過敏的人可能會在未來的某個時間擁有一隻貓。當然，真正的低
過敏性貓的創造還很遙遠。但是，科學家們相信他們可以使用基因編輯工具CRISPR來去除
負責產生導致貓過敏的蛋白質的基因。

How bad are cat allergies today?

今天貓過敏有多嚴重？

Cats are everywhere, plus they make great pets. That’s why dealing with cat
allergies has become such a huge problem for many people. A study from 2018
says that between 10 to 20 percent of the world’s population deals with cat
allergies of some kind. One of the big culprits of these allergies is a
protein called Fel d 1.

貓無處不在，而且它們是很棒的寵物。這就是為什麼處理貓過敏已成為許多人的大問題。
2018 年的一項研究表明，世界上有 10% 到 20% 的人口患有某種貓過敏症。這些過敏的
罪魁禍首之一是一種叫做 Fel d 1 的蛋白質。

When cats produce this protein, it ends up in their saliva and tears. It is
then transferred, obviously, to their fur through constant cleaning. From
there, it’s transferred to our homes as they shed their hair and it blends
with the dust around the house. It’s a constant cycle and one that has left
many people dealing with terrible allergies over the years.

當貓產生這種蛋白質時，它最終會出現在它們的唾液和眼淚中。然後通過不斷的舔毛梳理
，它會轉移到它們的皮毛上。當他們脫落貓毛時，它被轉移到我們的家中，並與房子周圍
的灰塵混合在一起。這是一個持續的循環，造成廣泛而可怕的過敏症。

Sure, there are some hypoallergenic cat breeds out there. However, they all
still create this protein, just some in lesser quantities. So, while they may
not produce Fel d 1 levels that are dangerous, they can still lead to an
allergic response over time.

當然，那裡有一些低過敏性的貓品種。然而，它們仍然會產生這種蛋白質，只是數量較少
。因此，雖然它們可能不會產生危險的 Fel d 1 水平，但隨著時間的推移，它們仍然會
導致過敏反應。

Making a truly hypoallergenic cat

做一隻真正的低度過敏貓

It’s this widespread allergy issue that has led scientists at the
Virginia-based biotech company InBio to investigate making a truly
hypoallergenic cat. The company published a study on the matter earlier this
week in The CRISPR Journal, detailing how they think they can accomplish this
goal.

正是這種普遍存在的過敏問題促使位於維吉尼亞州的生物技術公司 InBio 的科學家們研
究製造一隻真正的低過敏性貓。該公司本週早些時候在The CRISPR Journal上發表了一項
關於此事的研究，詳細說明了他們認為他們可以如何實現這一目標。

Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1

https://www.liebertpub.com/doi/10.1089/crispr.2021.0101

The scientists say they analyzed the DNA of 50 domestic cats and found
regions along two genes that they believe are primarily responsible for
producing Fel d 1. They also found that these regions may be suitable for
editing using CRISPR’s gene-editing technology. The researchers then
compared their domestic findings with those of eight wilder cat species.

科學家們說，他們分析了 50 隻家貓的 DNA，並發現了他們認為主要負責產生 Fel d 1
的兩組基因的區域。他們還發現這些區域可能適合使用 CRISPR 的基因編輯技術進行編輯
。然後，研究人員將他們的國內發現與八種野生貓科動物的發現進行了比較。

Here, they found a large discrepancy between the levels of Fed d 1 in the
different groups. This, they say, could indicate that Fel d 1 is not
essential to cat biology. As such, they believe they can remove it without
posing a health risk to the cats involved. They tested this theory by editing
cat cells in the lab using CRISPR. The results produced no off-target changes
in the areas where they thought it might occur.

在這裡，他們發現不同組的 Fed d 1 水平存在很大差異。他們說，這可能表明 Fel d 1
對貓的生物學不是必需的。因此，他們相信他們可以將其移除，而不會對所涉及的貓造成
健康風險。他們通過在實驗室中使用 CRISPR 編輯貓細胞來驗證這一理論。

Of course, there’s still a long way to go before these scientists start
breeding hypoallergenic cats. Still, it’s interesting to look at how tools
like CRISPR allow us to change things at a genetic level. We’ve also
recently seen gene-editing take a fascinating approach in genetically
modified mosquitos. Allowing scientists to create a subspecies capable of
helping cull the population of disease-carrying insects.

當然，在這些科學家開始培育低過敏性貓之前，還有很長的路要走。儘管如此，看看像
CRISPR 這樣的工具如何讓我們在基因水平上改變事物還是很有趣的。我們最近還看到基
因編輯在轉基因蚊子中採用了一種令人著迷的方法。允許科學家創造一個能夠幫助消滅攜
帶疾病的昆蟲種群的亞種。

5.完整新聞連結 (或短網址)需放媒體原始連結，不可用轉載媒體連結:

https://bgr.com/science/scientists-might-actually-create-hypoallergenic-cats/

6.備註:




這安全嗎？










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